Development of TPS flight test and operational instrumentation

Thermal and flow sensor instrumentation was developed for use as an integral part of the space shuttle orbiter reusable thermal protection system. The effort was performed in three tasks: a study to determine the optimum instruments and instrument installations for the space shuttle orbiter RSI and RCC TPS; tests and/or analysis to determine the instrument installations to minimize measurement errors; and analysis using data from the test program for comparison to analytical methods. A detailed review of existing state of the art instrumentation in industry was performed to determine the baseline for the departure of the research effort. From this information, detailed criteria for thermal protection system instrumentation were developed

Secondary analysis of an RCT on Emergency Department-Initiated Tobacco Control: Repeatedly assessed point-prevalence abstinence up to 12 months and extension of results through a 10-year follow-up.

INTRODUCTION:Emergency departments (EDs) are opportune places for tobacco control interventions. The 'Tobacco Control in an Urban Emergency Department' (TED) study, ISRCTN41527831, originally evaluated the effect of motivational interviewing on-site plus up to four booster telephone calls on 12-month abstinence. This study's aim was to evaluate the effect of the intervention on 7-day point-prevalence abstinence at 10 years follow-up (primary outcome) as well as on repeated point-prevalence abstinence at 1, 3, 6, 12 months and at 10 years (continual smoking abstinence, secondary outcome). METHODS:At the 10 years follow-up and after informed consent, study participants responded to a mailed questionnaire. The primary outcome was analyzed in observed-only and in all-cases analyses. The secondary outcomes were analyzed using a multiple adjusted GLMM for binary outcomes. RESULTS:Out of 1012 TED-study participants, 986 (97.4%) were alive and 231 (23.4% of 986) responded to the follow-up at 10 years. For observed-only and all-cases analyses, the effect of the baseline intervention on 7-day point-prevalence abstinence at the 10 years follow-up was statistically non-significant. However, when taking into account all repeated measures, the intervention significantly influenced continual abstinence with odds ratio 1.32 (95% CI: 1.01-1.73; p=0.042). Baseline motivation, perceived self-efficacy to stop smoking, and nicotine dependency were independently associated with long-term continual smoking abstinence (all p<0.05). CONCLUSIONS:A conventional analysis failed to confirm a significant effect of the ED-initiated tobacco control intervention on the point-prevalence abstinence at 10 years. Results from a more integrative analysis nonetheless indicated an enduring intervention effect on continual abstinence among smokers first encountered in the emergency department setting 10 years earlier

MAGICC:A Project of the EU Lifelong Learning programme: Modularising Multilingual and Multicultural Academic Communication Competence

This report introduces the ERASMUS project of the EU Lifelong Learning programme MAGICC: Modularising Multilingual and Multicultural Academic Competences (2011-2014). Conceived as a complement to the CEFR, the project's main objective was to develop a framework and instruments that can be used to conceptualize and evaluate multilingual and multicultural academic communication competences. Through the Bologna Process, these competences have been becoming increasingly important to students in higher education and therefore need to be integrated as graduate learning outcomes at BA and MA level. To that end, MAGICC provides a conceptual framework, pedagogical scenarios, transparency tools, an academic e-portfolio and an executive summary for future employers.In the final assessment, the project received 9/10 from the Education, Audiovisual and Culture Executive Agency (EACEA) and was evaluated as an excellent project. Furthermore, experts from the Directorate-General for Education and Culture of the European Commission call it a success story.</p

The role of combining national official statistics with global monitoring to close the data gaps in the environmental SDGs

The Sustainable Development Goals (SDGs) have elevated the profile of the environmental dimension of development – and how we monitor this dimension. However, they have also challenged national statistical systems and the global statistical community to put in place both the methodologies and mechanisms for data collection and reporting on environmental indicators. According to a recent analysis, there is too little data to formally assess the status of 68% of the environment-related SDGs [1]. Many environment-related indicators were not part of the purview of national statistical systems and did not have a methodology or data collection system in place prior to the adoption of the SDG indicator framework [2]. Moderate improvements have been made, as evidenced by the reduced proportion of environment-related SDG indicators classified as Tier III between the original classification in 2016 and May 2019 – dropping from 50% to 28% [3]. As of March 2020, there are currently no Tier III indicators; however, as many of the SDG indicators have been recently reclassified the data availability and experience in compiling these indicators is severely limited. Socioeconomic indicators have far outpaced environmental indicators in this shift, with only 7% of non-environmental indicators classified as Tier III in May 2019 [1,4,5]. As the custodian agency for 26 of the environment-related SDG indicators, UN Environment is establishing methodologies and mechanisms to collect country-level data. However, many countries currently do not have national systems in place for monitoring these environmental indicators and thus there is a risk that much of the environmental dimension of development cannot be captured by using reporting mechanisms which only include traditionally collected national official statistics. For many of these indicators, UN Environment is exploring new data sources, such as data from citizen science. Citizen science has the potential to contribute to global and local level SDG monitoring. Realizing its full potential however, would require building key partnerships around citizen science data and creating an enabling environment. Global modelling is another approach to fill data gaps. These new types of data could not only improve global estimations but could be incorporated in national official statistics in order to improve nationally relevant data and analysis [6]. The Global Material Flow database, which estimates Domestic Material Consumption (covering SDG indicators 8.4.2 and 12.2.2), and the Global Surface Water Explorer application (covering SDG indicator 6.6.1) are a couple of examples of where UN Environment is complementing national data with global data products in the official SDG reporting process. In these cases the use of globally-derived data has been agreed by the Inter-Agency and Expert Group on SDG Indicators (IAEG-SDGs) [7]. Expanding globally-estimated or -modelled data to cover environment-related SDG indicators could build the foundation for a digital ecosystem for the planet, which would provide a basis for developing integrated analysis and insights. A Sustainability Gap Index could be one mechanism to bring together the environmental dimension of development into a single metric, which could inform the achievement of the SDGs, environmental assessments and national policy. This paper presents a summary of how the world is faring in terms of measuring the environmental dimension of the SDGs

Nano-oxidation of silicon surfaces: Comparison of noncontact and contact atomic-force microscopy methods

3 pages, 4 figures.Local oxidation lithography by atomic-force microscopy is emerging as a powerful method for nanometer-scale patterning of surfaces. Here, we perform a comparative study of contact and noncontact atomic-force microscopy (AFM) oxidation experiments. The comparison of height and width dependencies on voltage and pulse duration allows establishing noncontact AFM as the optimum local oxidation method. For the same electrical conditions, noncontact AFM oxides exhibit higher aspect ratios (0.04 vs 0.02). The smallness of the liquid meniscus in noncontact AFM oxidation produces smaller oxide widths. We also report a slower oxidation rate in contact AFM oxidation. We explain this result by introducing an effective energy barrier (~0.14 eV) that includes the mechanical work done by the growing oxide against the cantilever (~0.01 eV).This work was financially supported by the Dirección General de Enseñanza Superior e Investigación (PB98-0471) and the European Commission (GR5D-CT- 2000-00349).Peer reviewe

Coulomb plasmas in outer envelopes of neutron stars

Outer envelopes of neutron stars consist mostly of fully ionized, strongly coupled Coulomb plasmas characterized by typical densities about 10^4-10^{11} g/cc and temperatures about 10^4-10^9 K. Many neutron stars possess magnetic fields about 10^{11}-10^{14} G. Here we briefly review recent theoretical advances which allow one to calculate thermodynamic functions and electron transport coefficients for such plasmas with an accuracy required for theoretical interpretation of observations.Comment: 4 pages, 2 figures, latex2e using cpp2e.cls (included). Proc. PNP-10 Workshop, Greifswald, Germany, 4-9 Sept. 2000. Accepted for publication in Contrib. Plasma Phys. 41 (2001) no. 2-

«Smarter Medicine»: 5 Interventionen, die in der ambulanten allgemeinen inneren Medizin vermieden werden sollten

Seit 2012 befasst sich die Schweizerische Gesellschaft für Allgemeine Innere Medizin mit der Problematik der Überdiagnostik und Überversorgung in der Medizin. Nun hat sie beschlossen, eine Liste mit fünf Untersuchungen auf dem Gebiet der ambulanten allgemeinen inneren Medizin zusammenzustellen, die ohne oder mit nur geringem Nutzen bei zahlreichen Patienten durchgeführt werden, gleichzeitig jedoch unerwünschte Nebenwirkungen haben können und zum Anstieg der Gesundheitskosten beitragen

Evaluation of a hybrid antimicrobial restriction process at a large academic medical center

We conducted a retrospective review of a hybrid antimicrobial restriction process demonstrating adherence to appropriate use criteria in 72% of provisional-only orders, in 100% of provisional orders followed by ID orders, and in 97% of ID-initiated orders. Therapy interruptions occurred in 24% of provisional orders followed by ID orders

Translational approaches to understanding resilience to Alzheimer\u27s disease.

Individuals who maintain cognitive function despite high levels of Alzheimer\u27s disease (AD)-associated pathology are said to be \u27resilient\u27 to AD. Identifying mechanisms underlying resilience represents an exciting therapeutic opportunity. Human studies have identified a number of molecular and genetic factors associated with resilience, but the complexity of these cohorts prohibits a complete understanding of which factors are causal or simply correlated with resilience. Genetically and phenotypically diverse mouse models of AD provide new and translationally relevant opportunities to identify and prioritize new resilience mechanisms for further cross-species investigation. This review will discuss insights into resilience gained from both human and animal studies and highlight future approaches that may help translate these insights into therapeutics designed to prevent or delay AD-related dementia